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CompTIA Security+ study material · question 552 of 611
A laptop with full-disk encryption is stolen while running and unlocked. What protection remains?
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Answer: B. Little, because the key is unlocked and in memory while the system is in use
Disk encryption protects data at rest on a powered-off device, which is a different situation from a running one.
Source: NIST SP 800-88 Rev. 1 (NIST) — SP 800-88 Rev. 1 § 2.6 Use of Cryptography and Cryptographic Erase